Process for the preparation of acid chlorides
AssigneeParke, Davis & Company
InventorOm P. Goel
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Abstract
A process for the production of 6-(disubstituted amino)phenyl-1,2-dihydro-2-oxonicotinyl chloride hydrochlorides, which comprises exposing the dry, finely divided corresponding 6-(disubstituted amino)phenyl-1,2-dihydro-2-oxonicotinic acid or its hydrochloride to gaseous thionyl chloride utilizing reduced atmospheric pressures. The 6-(disubstituted amino)phenyl-1,2-dihydro-2-oxonicotinyl chloride hydrochlorides are useful as intermediates in the preparation of useful semisynthetic antibiotics.
Claims4
A process for the production of a 6-(disubstituted amino)phenyl-1,2-dihydro-2-oxonicotinyl chloride hydrochloride having the formula ##SPC12##
- which comprises reacting a compound of the formula ##SPC13##
- or an acid addition salt thereof having a particle size of less than eight microns, wherein R is hydrogen or methyl;
- R.sub.1 and R.sub.2 are branched or straight chain lower alkyl groups of from one to six carbon atoms, or R.sub.1 R.sub.2 N taken together form 4-R.sub.3 -1-piperazino, 4-methyl-1-homopiperazino, 1-pyrrolidino, morpholino, 1-piperidino, 4-(1-pyrrolidino)piperidino or 4-(1-piperidino)piperidino, wherein R.sub.3 is a lower alkyl group of from one to six carbon atoms, cyclohexyl, benzyl, phenyl, halophenyl wherein halo represents chloro, fluoro, bromo, or iodo, with thionyl chloride at a pressure of about 0.1 to about 0.5 atmospheres and wherein said thionyl chloride is in the gaseous phase.
Dependencies are inferred from the claim text.