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US 3,946,005 AGranted
7-Amino-3-(1,2,4-triazolinylthiomethyl)cephalosporins
AssigneeSmithKline Corporation
InventorDavid Alan Berges
Life of this patent
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Abstract
Cephalosporins containing a heterocyclicthiomethyl group at position 3 are prepared. The heterocyclic group is 5-oxo-.DELTA..sup.2 -1,2,4-triazolinyl, 5-thiono-.DELTA..sup.2 -1,2,4-triazolinyl, 5-oxo-.DELTA..sup.2 -1,2,4-thiadiazolinyl or 5-thiono-.DELTA..sup.2 -1,3,4-thiadiazolinyl. The compounds have antibacterial activity.
Claims5
A compound of the formula ##SPC3##
- wherein
- Z is NR;
- A is O or S;
- R is hydrogen or C.sub.1 -C.sub.4 alkyl;
- and
- M is hydrogen, 2,2,2-trichloroethyl, benzhydryl, t-butyl, p-nitrophenyl, p-methoxyphenyl, p-methoxybenzyl, or benzyloxymethyl.
3 more elements
Dependencies are inferred from the claim text.