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US 3,946,003 AGranted
Hydroxy substituted phenylglycylamido-3-heterocyclic thiomethyl cephalosporins
AssigneeEli Lilly and Company
InventorRobin D. G. Cooper
Life of this patent
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Abstract
7-(4-Hydroxyphenylglycylamido)-3-(1-methyl-1H-tetrazolyl-5-thiomethyl)-3-ce phem-4-carboxylic acid, 7-(4-hydroxyphenylglycylamido)-3-(5-methyl-1,3,4-thiadiazolyl-2-thiomethyl )-3-cephem-4-carboxylic acid, the corresponding 3-hydroxy isomers and the pharmaceutically acceptable, non-toxic salts thereof are orally effective antibiotics exhibiting high blood levels.
Claims3
The cephalosporin compound of the formula ##SPC15##
- wherein R is the 1-methyl-1H-tetrazol-5-yl group of the formula ##SPC16##
- or the 5-methyl-1,3,4-thiadiazol-2-yl group of the formula ##SPC17##
- and R.sub.1 is selected from the group consisting of 5-indanyl, phthalidyl, and an acyloxymethyl group of the formula ##EQU4## wherein A is C.sub.1 -C.sub.4 alkyl or phenyl.
Dependencies are inferred from the claim text.