(Carbamoylthi oacetyl)cephalosporin derivatives
AssigneeE. R. Squibb & Sons, Inc.
InventorsUwe D. Treuner, Hermann Breuer
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Abstract
(Carbamoylthioacetyl)cephalosporin derivatives of the general formula ##EQU1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)stannyl, tri(lower alkyl)silyl, a salt forming ion or the group ##EQU2## R.sub.1 is hydrogen, lower alkyl, phenyl, thienyl or furyl; R.sub.2 is lower alkyl, lower alkoxymethyl, phenyl or phenyl-lower alkyl; R.sub.3 is hydrogen, hydroxy or lower alkanoyloxy; and R.sub.4 is lower alkyl, phenyl or phenyl-lower alkyl; are useful as antibacterial agents.
Claims12
A compound of the formula ##EQU10## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)stannyl, tri(lower alkyl)silyl, ##EQU11## alkali metal, alkaline earth metal, tri-lower alkylamine salt or (lower alkyl)amine salt;
- R.sub.1 is phenyl;
- R.sub.2 is lower alkyl, lower alkoxymethyl, phenyl or phenyl-lower alkyl;
- R.sub.3 is hydrogen, hydroxy or lower alkanoyloxy;
- and R.sub.4 is lower alkyl, phenyl or phenyl-lower alkyl;
- said lower alkyl and lower alkanoyloxy groups having up to seven carbon atoms.
A compound of the formula ##EQU12## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)stannyl, tri(lower alkyl)silyl, ##EQU13## alkali metal, alkaline earth metal, tri(lower alkyl)amine salt or (lower alkyl)amine salt;
- R.sub.1 is thienyl;
- R.sub.2 is lower alkyl, lower alkoxymethyl, phenyl or phenyl-lower alkyl;
- R.sub.3 is hydrogen, hydroxy or lower alkanoyloxy;
- and R.sub.4 is lower alkyl, phenyl or phenyl-lower alkyl;
- said lower alkyl and lower alkanoyloxy groups having up to seven carbon atoms.
Dependencies are inferred from the claim text.