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US 3,946,000 AGranted
7-[.alpha.-(2-Aminomethyl-1-cyclohexenyl)-acetamido]-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids
AssigneeBristol-Myers Company
InventorsTakayuki Naito, Jun Okumura, Hajime Kamachi
Life of this patent
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Abstract
7-[.alpha.-(2-Aminomethyl-1-cyclohexyl)-acetamido]-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids, and their nontoxic, pharmaceutically acceptable salts and their Schiff bases, as made by reaction of salicylaldehyde with the free amino group, are valuable as antibacterial agents and are particularly valuable as therapeutic agents in poultry and animals, including man, in the treatment of infectious diseases caused by many Gram-positive and Gram-negative bacteria.
Claims33
An acid having the formula ##SPC42##
- wherein R is ##SPC43## ##SPC44##
- or ##EQU1## or a nontoxic, pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.