Antiinflammatory and analgesic cycloalkano-pyrimidin-2(1H)-ones
AssigneeSandoz Ltd.
InventorWilliam G. Salmond
Life of this patent
Estimating the term…
Abstract
Anti-inflammatory and analgesic agents of the formula I: ##SPC1## wherein n is 2 to 7, R.degree. is lower alkyl, m is 0, 1 or 2, R is lower alkyl, alkenyl, cycloalkyl, cycloalkylalkyl or phenyl, R' is a radical of the formula ##SPC2## In which Y and Y' are the same or different and represent hydrogen, lower alkyl, lower alkoxy, halo of atomic weight of 19 to 36 or one of Y and Y' is trifluoromethyl while the other is hydrogen, or a radical of the formula ##SPC3## In which Y" is hydrogen, fluorine, chlorine or alkyl of 1 to 3 carbon atoms, are prepared by cyclizing a compound of the formula II ##SPC4## in which R, R', R.degree., m and n are as defined above, with, for example, phosgene.
Claims12
A compound of the formula:
- ##SPC16##
- wherein
- n is 2 to 7,
- R.degree. is alkyl of 1 to 3 carbon atoms,
- m is 0, 1 or 2.
- R is alkyl of 1 to 5 carbon atoms, cycloalkyl of 3 to 8 carbon atoms or cycloalkylalakyl of 4 to 10 carbon atoms in which the alkyl is of 1 to 3 carbon atoms and the cycloalkyl of 3 to 8 carbon atoms, and
- R' is a radical of the formula:
- ##SPC17##
- in which Y and Y' are independently hydrogen, fluoro, chloro, alkyl of 1 or 2 carbon atoms, alkoxy of 1 to 2 carbon atoms or one of Y and Y' is trifluoromethyl while the other is hydrogen, or a radical of the formula:
- ##SPC18##
- in which Y' is hydrogen, fluoro, chloro or alkyl of 1 to 3 carbon atoms.
Dependencies are inferred from the claim text.