Nitrogen-containing compounds
AssigneeImperial Chemical Industries PLC
InventorLeslie Harold Smith
Life of this patent
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Abstract
Novel 1-aryl-2-amidoalkylaminoethanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity. Representative of the compounds disclosed is 1-phenyl-2-(1,1-dimethyl-2-phenylacetamidoethyl)amino-ethanol.
Claims7
An ethanolamine derivative selected from the group consisting of compounds of the formula:
- ##SPC28##
- wherein A is alkylene of from 2 to 6 carbon atoms, wherein R.sup.1 is hydrogen or alkyl, alkenyl, halogenoalkyl or cycloalkyl each of up to 6 carbon atoms, or aryl of the formula:
- ##SPC29##
- wherein R.sup.2, R.sup.3, R.sup.12, and R.sup.13, which may be the same or different, each is hydrogen, halogen, nitro, amino or cyano, or alkyl alkenyl, alkoxy, alkenyloxy, hydroxalkyl, alkanoyl, acylamino each of up to 6 carbon atoms, wherein R.sub.4 is hydrogen, hydroxy or carbamoyl, wherein R.sup.5 is hydrogen or alkyl of up to 6 carbon atoms, wherein X is carbonyl and wherein Y is a direct link, or alkylene or alkyleneoxy each of up to 6 carbon atoms, or (except when R.sup.1 is hydrogen) oxygen, and the acid-addition salts thereof.
The compound 1-phenyl-2-(1-methyl-2-phenylacetamido-ethyl)aminoethanol or an acid-addition salt thereof.
The compound (1R)-1-phenyl-2-[(1R)-1-methyl-2-phenylacetamidoethyl]aminoethanol or (1R)-1-phenyl-2-[(1S)-1-methyl-2-phenylacetamidoethyl]aminoethanol or an acid-addition salt thereof.
Dependencies are inferred from the claim text.