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US 3,944,600 AGranted
Indenylidene-3-acetic acid process for preparing indene acetic acids
AssigneeMerck & Co., Inc.
InventorsRoger J. Tull, Robert F. Czaja, Richard F. Shuman, Seemon H. Pines
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Abstract
Process for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indene-3-acetic acid by reacting fluorobenzene with an acid halide, to form an indanone, reaction of the indanone with a methylthio (or methylsulfinyl)benzyl compound to form 5-fluoro-2-methyl-1-(p-methylthiobenzyl) or (p-methylsulfinylbenzyl)-indene and reacting said indene with a glyoxylic acid. The invention also relates to intermediates thereof and processes for said intermediates.
Claims1
A cis and trans compound of the formula:
- ##SPC2##
- wherein
- R.sub.1 is methylthio or methylsulfinyl.
Dependencies are inferred from the claim text.