.alpha.-Cycloalkenylphenyl-fatty acid nitriles
AssigneeCiba-Geigy Corporation
InventorAlberto Rossi
Life of this patent
Estimating the term…
Abstract
Compounds of the formula ##EQU1## in which X represents a free carboxyl group or in the second place an esterified or amidated carboxyl group; R represents a 1-cycloalkenyl residue; Ph represents an ortho-phenylene residue or especially a para-phenylene residue; and R.sub.1 and R.sub.2 each represents a hydrogen atom or a monovalent or together a divalent aliphatic or araliphatic hydrocarbon residue, e.g. the .alpha.-[p-(1-cyclohexenyl)-phenyl]-propionic acid, are useful as analgetic and antiinflammatoric agents.
Claims3
A member selected from the group consisting of compounds of the formula ##EQU11## in which Ph stands for a member selected from the group consisting of ortho-phenylene, ortho-phenylene substituted by a member selected from the group consisting of lower alkyl, lower alkoxy, halogen, trifluoromethyl, amino, nitro and hydroxy, para-phenylene and paraphenylene substituted by a member selected from the group consisting of lower alkyl, lower alkoxy, halogen, trifluoromethyl, amino, nitro and hydroxy, R stands for a member selected from the group consisting of 1-cycloalkenyl having 4-8 ring carbon atoms and 1-cycloalkenyl having 4-8 ring carbon atoms substituted by a member selected from the group consisting of lower alkyl, lower alkoxy, lower alkenyloxy, hydroxy, oxo, amino, mono-lower alkylamino, di-lower alkylamino, lower alkyleneamino, lower oxaalkyleneamino, lower thiaalkyleneamino and lower azaalkyeneamino and R.sub.1 and R.sub.2 each stands for a member selected from the group consisting of hydrogen, lower alkyl, lower alkenyl, lower alkinyl, phenyl-lower alkyl, phenyl-lower alkyl substituted by a member selected from the group consisting of lower alkyl, lower alkoxy, halogen and trifluoromethyl, phenyl-lower alkenyl and phenyllower alkenyl substituted by a member selected from the group consisting of lower alkyl, lower alkoxy, halogen and trifluoromethyl, and when taken together R.sub.1 and R.sub.2 stand for lower alkylidene.
Dependencies are inferred from the claim text.