Novel pregnane-21-oic acid derivatives
AssigneeSchering Corporation
InventorsHenry Laurent, Rudolf Wiechert
Life of this patent
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Abstract
Pregnane-21-oic acids of the formula ##SPC1## Wherein X is a hydrogen atom, a fluorine atom, or methyl; Y is a hydrogen atom, a fluorine atom, or a chlorine atom; Z is methylene, carbonyl, .beta.-hydroxymethylene, .beta.-acyloxymethylene or when Y is a chlorine atom, .beta.-fluoromethylene or .beta.-chloromethylene; V is methylene, ethylidene or vinylidene; R.sub.1 is a hydrogen atom or acyl, and physiologically acceptable salts thereof with bases and physiologically acceptable 21-esters thereof, possess topical anti-inflammatory activity with substantially no systemic activity.
Claims53
A pregnane-21-oic acid derivative of the formula ##SPC8##
- wherein X is a hydrogen atom, a fluorine atom, or methyl;
- Y is a hydrogen atom, a fluorine atom, or a chlorine atom;
- Z is methylene, carbonyl, a .beta.-hydroxymethylene, .beta.-acyloxymethylene whereby acyl is the acyl radical of a hydrocarbon carboxylic acid of 1-8 carbon atoms, or when Y is a chlorine atom, .beta.-fluoromethylene or .beta.-chloromethylene;
- V is >CH.sub.2, >CHCH.sub.3 or >
- C=CH.sub.2 ;
- R.sub.1 is a hydrogen atom or the acyl radical of a hydrocarbon carboxylic acid of 1-8 carbon atoms, and R.sub.2 is a hydrogen atom or alkyl of 1-8 carbon atoms, and the bond represents a single or double bond, and, when R.sub.2 is H, the physiologically acceptable metal and ammonium salts thereof.
Dependencies are inferred from the claim text.