Novel steroids of the oestrane series substituted in 7-position
AssigneeAkzona Incorporated
InventorsAlbertus Joannes van den Broek, Jacob DE Visser
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AssigneeAkzona Incorporated
InventorsAlbertus Joannes van den Broek, Jacob DE Visser
Estimating the term…
The invention relates to novel 7-substituted-steroids of the oestrane series of the general formula: ##SPC1## In which Ring A including carbon atom 6 is ##SPC2## R.sub.1 = an alkyl group with 1-4 C-atoms, R.sub.2 = oxygen or (.alpha.Y)(.beta.Z), in which Y = hydrogen or a saturated or unsaturated alkyl group with 1-4 C-atoms and Z = a free, esterified or etherified hydroxyl group, R.sub.3 = hydrogen or a free or esterified hydroxyl group, R.sub.4 = an alkylene- or alkylidene group with 1-3 C-atoms, R.sub.5 = hydrogen or a free, esterified or etherified hydroxyl group, R.sub.6 = H.sub.2, O, H(OH), H(Oalkyl) or H(Oacyl), X = H, an acyl group or an alkyl-, aralkyl-, cycloalkyl- or heterocyclic alkyl group, and A double bond is present starting from carbon atom 5, and to processes for their preparation. These novel steroids possess anabolic, androgenic, oestrogenic, progestative, ovulation-inhibiting and gonad-inhibiting properties.
A 7-substituted steroid of the oestrane series, selected from the group consisting of 7.alpha.-methoxymethyl-17.alpha.-ethynyl-.DELTA..sup.4 -oestren-17.beta.-ol, 7.alpha.-methoxymethyl-17.alpha.-ethynyl-.DELTA..sup.1,3,5(10) -oestratriene-3,17.beta.-diol, 7.alpha.-hydroxymethyl-17.alpha.-ethynyl-.DELTA..sup.1,3,5(10) -oestratriene-3,17.beta.-diol, and 7.alpha.-methoxymethyl-.DELTA..sup.1,3,5(10) -oestratriene-3,16.alpha.,17.beta.-triol.
7.alpha.-methoxymethyl-17.alpha.-ethynyl-.DELTA..sup.4 -oestren-17.beta.-ol.
7.alpha.-methoxymethyl-17.alpha.-ethynyl-.DELTA..sup.1,3,5(10) -oestratriene-3,17.beta.-diol.
7.alpha.-hydroxymethyl-17.alpha.-ethynyl-.DELTA..sup.1,3,5(10) -oestratriene-3,17.beta.-diol.
7.alpha.-methoxymethyl-.DELTA..sup.1,3,5(10) -oestratriene-3,16.alpha.,17.beta.-triol.
Dependencies are inferred from the claim text.