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US 3,944,571 AGranted
Ester derivatives of pulvinic acid
AssigneeSmithKline Corporation
InventorsBlaine M. Sutton, Donald T. Walz, James W. Wilson
Life of this patent
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Abstract
Pharmaceutical compositions having anti-arthritic activity comprising an ester derivative of pulvinic acid and methods of producing anti-arthritic activity by administering internally said compositions. Certain of the pulvinic acid derivatives are novel compounds per se.
Claims5
A chemical compound of the formula:
- ##SPC5##
- in which:
- R is methyl or ethyl;
- and
- R.sub.1 and R.sub.2 are substituents selected as follows so that for a given R.sub.1 in column 1 the corresponding R.sub.2 is in the adjacent position of column 2:
- R.sub.1 R.sub.2 ______________________________________ hydrogen 3-bromo-4-methoxy 3-bromo-4-methoxy hydrogen 2-methoxy-5 methyl 2-methoxy-5-methyl 3-chloro-4-fluoro 3-chloro-4-fluoro hydrogen 3,4-dichloro 4-methylthio hydrogen hydrogen 4-methylthio 4-methylsulfinyl hydrogen hydrogen 4-methylsulfinyl 4-methylthio 4-methylthio hydrogen 3-chloro-4-methoxy hydrogen 2-chloro-5-methyl 3-chloro-2-methyl hydrogen hydrogen 3-chloro-2-methyl. ______________________________________
3 more elements
Dependencies are inferred from the claim text.