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US 3,944,570 AGranted
3,3-Disubstituted phthalides
AssigneeSandoz Ltd.
InventorsWilliam J. Houlihan, Jeffrey Nadelson
Life of this patent
Estimating the term…
Abstract
Phthalanols disubstituted in the 3-position, e.g. 3-(4-chlorophenyl)-3-(2-dimethylaminomethyl phenyl)-1-methyl-1-phthalanol, prepared by alkylating corresponding phthalides, are useful as anti-inflammatory agents.
Claims2
A compound of the formula ##SPC5##
- where
- R.sub.2 and R.sub.3 each, independently, represent lower alkyl,
- or
- R.sub.2 and R.sub.3 together represent (CH.sub.2).sub.x
- where x represents 4, 5, 6 or 7, ##EQU2## where z represents O, S, or N-R.sub.4 where
- R.sub.4 represents lower alkyl,
- R.sub.5 and R.sub.6 each, independently, represent H, halo of atomic weight 19-36, lower alkyl, lower alkoxy or trifluorometyl,
- provided that R.sub.6 may not represent halo at the 6-position or lower alkyl at the 7-position,
- or an acid addition salt thereof.
6 more elements
Dependencies are inferred from the claim text.