N-Coumaranyl and chromanyl -methyl-or sulfur analogs thereof-N'- thiazolyl piperazines
AssigneeScience Union et Cie
InventorsGilbert Regnier, Roger Canevari, Michel Laubie, Jean-Claude Poignantw
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Abstract
Disubstituted piperazines of the formula: ##SPC1## Wherein: n is 1 or 2; X is oxygen or sulfur; R is hydrogen or lower alkyl; Het is pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, quinolyl, quinazolyl, thiazolyl or benzothiazolyl, each optionally substituted by one or more lower alkyl, lower alkoxy, phenyl, amino, mono or di-lower-alkylamino, or hydroxy, and, ##SPC2## Is always bonded to the benzene ring. These compounds are used as medicines especially in the treatment of peripheral vascular disorders, Parkinson's disease, hypertension and as antipregnancy drugs.
Claims9
A compound selected from the group consisting of:
- A. disubstituted piperazines of the formula I:
- ##SPC17##
- wherein:
- n is selected from 1 and 2;
- X is selected from the group consisting of oxygen and sulfur;
- R is selected from the group consisting of hydrogen and alkyl having from 1 to 3 carbon atoms inclusive;
- Het is selected from the group consisting of thiazolyl, methyl thiazolyl benzothiazolyl, and ##SPC18##
- is always bonded to the benzine ring, and,
- B. physiologically tolerable acid addition salts thereof.
Dependencies are inferred from the claim text.