Amino derivatives of 1,4-benzodioxan
AssigneeLaboratoire L. Lafon
InventorLouis Lafon
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Abstract
1-[2-(1,4-benzodioxanyl)methyl]-4-(2-hydroxyethyl)-piperazine hemifumarate and the related compounds of formula: ##SPC1## In which R is hydrogen or alkyl; and A is --Z--OR.sub.1, --CH.sub.2 CHOR".sub.1 CH.sub.2 OR'.sub.1, --Z--CO--B or amidino, where Z is a linear or branched divalent hydrocarbon chain of 1 to 3 carbon atoms, R'.sub.1 and R".sub.1, which may be identical or different, are each hydrogen, alkyl, or acyl, B is OH, alkoxy, or a secondary, tertiary or N-heterocyclic amino radical, and R.sub.1 is alkyl, acyl other than nicotinoyl or 3,4,5-trimethoxy-benzoyl, or, when R is other than hydrogen, hydrogen, and its acid addition salts, are useful in therapy as vasodilators and .alpha.-blocking agents.
Claims8
The compound 1-[2-(1,4-benzodioxanyl)-methyl]-4-(2-hydroxyethyl)-piperazin hemifumarate.
The compound 1-[2-(1,4-benzodioxanyl)-methyl]-4-(2,3-dihydroxypropyl)-piperazine dihydrochloride.
The compound 1-[2-(6- or 7-methyl-1,4-benzodioxanyl)-methyl]-4-(2-hydroxyethyl)-piperazine dihydrochloride.
The compound 1-[2-(6- or 7-{tertiary butyl}-1,4-benzodioxanyl)-methyl]-4-(2-hydroxyethyl)-piperazine dihydrochloride.
The compound 1-[2-(1,4-benzodioxanyl)-methyl]-4-[2-(propionyloxy)-ethyl]-piperazine dihydrochloride.
The compound 1-[2-(1,4-benzodioxanyl)-methyl]-4-[2-(acetyloxy)-ethyl]-piperazine dihydrochloride.
The compound 1-[2-(1,4-benzodioxanyl)-methyl]-4-(2-pyrimidinyl)-piperazine dihydrochloride.
The compound 1-[2-(1,4-benzodioxanyl)-methyl]-4-(2,6-dimethylacetanilido)-piperazine dihydrochloride.
Dependencies are inferred from the claim text.