22-Cyano-24-norcholanes
AssigneeAmerican Home Products Corporation
InventorsNedumparambil A. Abraham, Yvon Lefebvre
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Abstract
There are disclosed herein the 3.beta., 14-dihydroxy-,3.beta.,5,14-trihydroxy-, 3.beta.,12.beta.,14-trihydroxy- and 3.beta.,14,16.beta.-trihydroxy-21,23-epoxy-23-methoxy-24-nor-5.beta.,1 4.beta.-chola-20,22-diene-22-carbonitriles, as well as their corresponding 3-acetates, 3-propionates and 3-butyrates and their 3-digitosides and 3.beta.-cyamarosyl-glucosides as encountered in naturally-occuring starting materials. The compounds possess useful cardiotonic activity. Also included are the corresponding 22-cyano-5.beta.-card-20(22)-enolides, useful as intermediates in the preparation of the compounds of this invention and also as cardiotonic agents.
Claims3
A compound of formula ##SPC4##
- in which St--OR represents rings A, B, C and D of naturally-occuring 3.beta.-oxygenated aglycones with their respective substituents attached thereto selected from the group consisting of digitoxigenin, periplogenin, digoxigenin and gitoxigenin, and R represents a glycosidic group naturally associated with the above aglycones and in which the cyanolactone ring is attached to the steroid moiety St at position 17.beta..
21,23-Epoxy-14-hydroxy-23-methoxy-3.beta.-tridigitosy loxy-24-nor-5.beta.,14.beta.-chola-20,22-diene-22-carbonitrile.
Dependencies are inferred from the claim text.