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US 3,943,254 AGranted
Beta-adrenergic antagonists
AssigneeSmithKline Corporation
InventorsDonald F. Colella, Carl Kaiser
Life of this patent
Estimating the term…
Abstract
.alpha.-Aminomethyl-4-hydroxy-3-sulfamylbenzyl alcohols and 4-hydroxy-3-sulfamylphenethylamines are disclosed. These compounds have .beta.-adrenergic antagonist activity.
Claims7
A pharmaceutical composition having .beta.-adrenergic antagonist activity comprising an amount sufficient to produce .beta.-adrenergic antagonist activity of a compound of the formula ##SPC3##
- R is hydrogen or alkyl of C.sub.1 -C.sub.4 ;
- R' is alkyl of C.sub.1 -C.sub.6, cycloalkyl of C.sub.3 -C.sub.6, XC.sub.6 H.sub.4 (CH.sub.2).sub.2 CH(CH.sub.3), XC.sub.6 H.sub.4 (CH.sub.2).sub.2 C(CH.sub.3).sub.2, XC.sub.6 H.sub.4 CH.sub.2 C(CH.sub.3).sub.2, or XC.sub.6 H.sub.4 CH.sub.2 CH(CH.sub.3);
- X is hydrogen, hydroxy, or methoxy;
- and
- Y is hydrogen or hydroxy
- or a nontoxic pharmaceutically acceptable salt thereof, and a pharmaceutical carrier therefor.
3 more elements
Dependencies are inferred from the claim text.