Method for the preparation of medicinal capsules
AssigneeMeija Seika Co., Ltd.
InventorsToshiyuki Kobayashi, Kensuke Sunazuka, Takeshi Mayama, Akira Okada
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Abstract
A method for the preparation of gelatin capsules having a good disintegrating property, in which a material selected from the group consisting of a protein, an amino acid, a substance having at least one amino group, an antioxidant, monobasic sodium phosphate, and the mixture thereof is added to the encapsulated contents.
Claims1
In a method for preparation of a hard gelatin capsule disintegrating in about 2 to about 22 minutes, said capsule containing a measured dose of midecamycin antibiotic as a medicine for delivery to the stomach when said capsule is ingested orally, said medicine otherwise tending in time to retard the disintegration of said hard gelatin capsule to 19 to 21 minutes, the improvement wherein the increase in the hard gelatin capsule disintegration time with capsule age is at least partially arrested, and improved stability of the disintegration time, to within 2 to 6 minutes, is achieved, which comprises incorporating into said capsule at least about 25 parts by weight of a pharmaceutically acceptable additive consisting essentially of casein per 70 parts by weight of midecamycin.
Dependencies are inferred from the claim text.