(-)(Cis-1,2-epoxy propyl)phosphonic acid amides
AssigneeMerck & Co., Inc.
InventorsBurton G. Christensen, Michael W. Fordice, David B. R. Johnston
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Abstract
Amides and thioates of (-)(cis-1,2-epoxypropyl)-phosphonic acid and phosphonothioic acid are prepared by converting (-)(cis-1,2-epoxypropyl)phosphonic acid or phosphonothioic acid or a salt thereof to an acid halide and reacting the acid halide with an amine, and by reacting the phosphonic acid or a salt thereof with an amine in the presence of a carbodiimide. The novel (-)(cis-1,2-epoxypropyl)phosphonic and phosphonothioic amides are active antibacterial agents.
Claims3
A (-) compound of the formula ##EQU25## wherein R.sub.6 and R.sub.7 are loweralkyl and n is an integer from 0-2.
P-(-)-(cis-1,2-epoxypropyl) -N,N'-dimethyl-N,N'-ethylenephosphonic diamide.
Dependencies are inferred from the claim text.