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US 3,943,147 AGranted
Process for imidazo isoindoles
AssigneeSandoz Ltd.
InventorWilliam J. Houlihan
Life of this patent
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Abstract
Imidazo isoindoles, e.g. 5-(p-chlorophenyl)-5-hydroxy-2,3-dihydro-5H-imidazo[2,1a]isoindol, may be prepared by treating a corresponding 2-benzoyl benzoic acid with a substituted ethylene diamine, and treating a resulting intermediate first with concentrated acid and then with base. The products are active as anorexic agents.
Claims6
A process for preparing a compound of the formula ##SPC6##
- which comprises a first step of treating a compound of the formula ##SPC7## with a compound of the formula ##EQU2## in inert solvent at a temperature of about 75.degree.-115.degree.C. to obtain an intermediate compound of the formula ##SPC8##
- treating said intermediate in a second step with concentrated sulfuric acid or phosphoric acid, and treating the resulting product with base,
- where X represents H or halo of atomic weight 19 to 36, and
- R represents lower alkyl, or ##SPC9##
- where R.sub.1 represents H, straight chain lower alkyl having 1 to 3 carbon atoms, or halo of atomic weight 35 to 80, and
- n is 1 or 2.
3 more elements
Dependencies are inferred from the claim text.