6-Phenyl-4H-v-triazolo[1,5-a][1,4]benzodiazepines
AssigneeCiba-Geigy Corporation
InventorsAndre Gagneux, Roland Heckendorn, Rene Meier
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Abstract
Compounds of the class of 6-phenyl-4H-v-triazolo[1,5-a][1,4] benzodiazepines, which in the 3-position are unsubstituted or substituted, particularly by a carbamoyl group or a substituted carbamoyl group, their 5-oxides and their pharmaceutically acceptable acid addition salts have valuable pharmacological properties and are active ingredients for therapeutic compositions. In particular, these new compounds have an anticonvulsive and anti-aggressive action. Specific embodiments are N,N-dimethyl-6-phenyl-8-chloro-4H-v-triazolo [1,5-a][1,4]benzodiazepine-3-carboxamide and N,N-dimethyl-6-(o-fluorophenyl)-8-chloro-4H-v-triazolo [1,5-a][1,4]benzodiazepine-3-carboxamide.
Claims23
A new diazepine derivative of formula I ##SPC8##
- in which R.sub.1 represents hydrogen, hydroxymethyl, formyl, carboxy, lower alkoxycarbonyl, or a group of formula Ia ##EQU5## in which R.sub.2 and R.sub.3 independently of each other represent hydrogen or lower alkyl, or a group of formula Ib ##EQU6## in which R.sub.2 and R.sub.3 have the meanings defined above, ring B is unsubstituted or substituted in the 8-position by halogen up to atomic number 35, trifluoromethyl or nitro, and ring C is unsubstituted or substituted by one substituent of the group of halogen atoms up to atomic number 35, trifluoromethyl and nitro, and its 5-oxide and its pharmaceutically acceptable addition salts with inorganic and organic acids.
Dependencies are inferred from the claim text.