Back to results
US 3,943,137 AGranted
Acronycine derivatives
AssigneeUniversity of Kansas Endowment Association
InventorsTakeru Higuchi, Arnold J. Repta, David W. A. Bourne
Life of this patent
Estimating the term…
Abstract
Acronycine derivatives having the structural formula: ##SPC1## Wherein R is acyl and A is an anion of a suitably strong acid, stabilized formulations thereof and pharmaceutical compositions comprised of same exhibit broad spectrum antitumor activity, and are especially suited for intravenous administration.
Claims10
An acronycine compound of the formula:
- ##SPC5##
- wherein R is straight or branched chain lower alkyl or halo alkyl having from 1 to 8 carbon atoms or phenyl or naphthyl, alkaryl or aralkyl wherein the aryl thereof is phenyl or naphthyl and the alkyl thereof is as above defined and A is a pharmaceutically acceptable anion of a strong quaternizing acid.
An intermolecular complex of (1) an acronycinium salt of the formula:
- ##SPC6##
- wherein R is straight or branched chain lower alkyl or halo alkyl having from 1 to 8 carbon atoms or phenyl or naphthyl, alkaryl or aralkyl wherein the aryl thereof is phenyl or naphthyl and the alkyl thereof is as above defined and A is a pharmaceutically acceptable anion of a strong quaternizing acid, and (2) a complexing agent selected from the group consisting of gentisic acid, gamma-resorcylic acid, p-hydroxycinnamic acid, 2-furoic acid, m-hydroxycinnamic acid, 3,4-dimethylcinnamic acid, 3-methyl gentisic acid and the pharmaceutically acceptable non-radioactive alkali metal salts thereof.
Dependencies are inferred from the claim text.