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US 3,943,127 AGranted
7-Trifluoromethylsulfinylacetamido cephalosporins
AssigneeSmithKline Corporation
InventorsRobert M. DeMarinis, John R. E. Hoover
Life of this patent
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Abstract
Cephalosporin compounds having a trifluoromethylsulfinylacetamido group at the 7-position and various groups at the 3-position are prepared by acylation of a 7-aminocephalosporanic acid. The compounds have antibacterial activity.
Claims2
A compound of the formula:
- ##SPC2##
- in which:
- M is hydrogen or an alkali metal or ammonium cation;
- and
- A is acetoxymethyl, methyl or pyridiniummethyl [, pyridiniummethyl, CH.sub.2 SHet, CH.sub.2 SR' or CH.sub.2 OR', where R' is hydrogen or alkyl of from one to four carbon atoms;
- and
- Het is a five or six membered heterocyclic group containing carbon and one to four atoms selected from the group consisting of N, O and S, each such group being unsubstituted or substituted with from one to two groups selected from lower alkyl, alkoxyalkyl, and trifluoromethyl, each alkyl or alkoxy having from one to four carbon atoms, or an N-oxide thereof].
4 more elements
Dependencies are inferred from the claim text.