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US 3,943,123 AGranted
Novel beta-lactams and novel process
AssigneeKoninklijke Nederlandsche Gist-en Spiritusfabriek N.V.
InventorAjay K. Bose
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AssigneeKoninklijke Nederlandsche Gist-en Spiritusfabriek N.V.
InventorAjay K. Bose
Estimating the term…
Novel .beta.-lactams containing a free carboxylic group of the formula: ##EQU1## wherein A and B are each selected from the group consisting of alkyl, including but not limited to branched alkyl, aryl, aralkyl and monocyclic heterocyclic groups at least one of A and B having a free carboxylic group. Further potential substituents of A and B are members of the group consisting of hydroxy, alkoxy, halogen, nitro, --NH.sub.2, monoalkylamino and dialkylamino groups, X is selected from the group consisting of hydrogen, alkyl, aryl and monocyclic heterocyclic, Y is selected from the group consisting of hydrogen, alkyl and aryl, and Z is selected from the group consisting of alkyl, alkoxy, aryloxy, aralkoxy, alkylthio, arylthio, aralkylthio, --CN, --COO-alkyl and --N.sub.3, useful as antibiotics and for the preparation of polymers and .beta.-amino acids, novel process for their preparation and novel imines used as starting materials for the said .beta.-lactams.
A .beta.-lactam of the formula ##EQU11## wherein A and B are each selected from the group consisting of phenyl, phenyl lower alkyl of 1 to 7 alkyl carbon atoms and furyl with A or B being substituted with a carboxyl and the other group being optionally substituted with a member of the goup consisting of hydroxy, 1 to 2 lower alkoxy, nitro and diloweralkylamino, and Z is selected from the group consisting of lower alkoxy, phenoxy, phthalimido and --N.sub.3.
Dependencies are inferred from the claim text.