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US 3,943,119 AGranted
Tuberculin active proteins and peptides from the cells of tubercle bacilli
AssigneeMitsui Pharmaceuticals, Inc.
InventorsToru Tsumita, Seishi Kuwabara
Life of this patent
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Abstract
Tuberculin active simple proteins and peptides which have the following peptide linkage --Asn--Gly--Ser--Gln--Met-- as a tuberculin active functional group, and a process for preparing the same from the cells of tubercle bacilli.
Claims3
A tuberculin active simple protein from Mycobacterium tuberculosis strain Aoyama B which is characterized by the following amino acid sequence:
- ##EQU3## wherein Asn and Gln represent asparagine residue and glutamine residue, respectively, and the remaining abbreviations represent the usual meanings and wherein the cysteine residues at positions 27 and 59 form one intra-chain disulfide bridge, said protein also being characterized by the following amino acid composition per molecule:
- Lys 4, His 1, Arg. 4, Cys 2, Asp 11 (containing one asparagine residue), Thr 5, Ser 4, Glu 11 (containing one glutamine residue), Pro 5, Gly 7, Ala 11, Val 8, Met 1, I1e 4, Leu 7, Tyr 2 and Phe 2.
A tuberculin active pentapeptide whose amino acid sequence is as follows. ##EQU4##
Dependencies are inferred from the claim text.