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US 3,941,886 AGranted
Pharmaceutical compositions containing crystalline racemic 9.alpha., 11.alpha., 15(S)-trihydroxy-5-cis, 13-trans-prostadienoic acid
AssigneeAlza Corporation
InventorNed M. Weinshenker
Life of this patent
Estimating the term…
Abstract
The invention concerns a novel crystalline racemate, 9.alpha. , 11.alpha. , 15(S)-trihydroxy-5-cis,13-trans-prostadienoic acid. The racemate can be administered in pharmaceutical dosage forms or from a drug delivery device at a programmed rate for producing smooth muscle stimulation, termination of pregnancy, induction of labor or induction of menses.
Claims1
A pharmaceutical composition comprising from 0.01 micrograms to 250 milligrams of crystalline, racemate 9.alpha.,11.alpha.,-15(S)-trihydroxy-5-cis,13-trans-prostadienoic acid wherein the crystals are characterized by the following X-ray diffraction data:
- Interplanar Spacings, A ______________________________________ 27.60 4.65 18.19 4.09 13.00 3.54 10.33 3.30 8.38 2.98 7.31 2.79 6.06 2.63 5.40 2.53 4.92 2.04 4.67 ______________________________________
- and wherein the crystals system is monoclinic, the crystal habit is tubular, the optic sign is negative, and the melting point is 63.5.degree.C to 64.degree.C, mixed with a pharmaceutical carrier.
Dependencies are inferred from the claim text.