Amino derivatives of 2,2-diaryl-cyclopropane
AssigneeSociete Anonyme dite: Hexachimie
InventorJean-Claude Gognaco
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Abstract
The present invention relates to compounds of the general formula ##SPC1## In which R represents the hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; R.sub.1 represents the hydrogen atom, a lower alkyl group, preferably methyl, or an aralkyl group; A represents an alkylene group; and R.sub.0 represents the hydrogen atom or an acyl group; and their acid addition salts as new industrial products. These new products are suitable for use in the treatment of cardiac disorders.
Claims9
2,2-diarylcyclopropane derivatives selected from the group consisting of:
- a. the compounds corresponding to the formula:
- ##SPC12##
- in which R represents H, Cl, F, CH.sub.3, OCH.sub.3 ;
- A represents C.sub.1 -C.sub.5 alkylene group, R.sub.1 represents H, CH.sub.3 ;
- R.sub.0 is a benzoyl group of the formula ##SPC13##
- in which R.sub.2, R.sub.3 and R.sub.4, which may be the same or different, each represent H, Cl, NO.sub.2, CH.sub.3, OCH.sub.3.
N-(2,2-Diphenylcyclopropylmethyl)-.gamma.-aminopropyl-3,4,5-trimethoxy benzoate and its acid addition salts.
N-(2,2-Diphenylcyclopropylmethyl)-.mu.-aminopropyl benzoate and its acid addition salts.
N-(2,2-Diphenylcyclopropylmethyl)-.gamma.-aminopropyl-2-chlorobenzoate and its acid addition salts.
N-(2,2-Diphenylcyclopropylmethyl)-.gamma.-aminopropyl-3-nitrobenzoate and its acid addition salts.
N-Methyl-N-[(2,2-diphenylc yclopropyl)-methyl]-.beta.-aminoethyl-3,4,5-trimethoxybenzoate and its acid addition salts.
N-[(2,2-Di-p-tolylcyclopropyl)-methyl]-.gamma.-aminopropyl-2-methyl benzoate and its acid addition salts.
N-[(2,2-Di-p-methoxyphenylcycloprop yl)-methyl]-.gamma.-aminopropyl-3,4,5-trimethoxybenzoate and its acid addition salts.
N-[(2,2-Di-p- fluorophenylcyclopropyl)-methyl]-.gamma.-aminopropyl-3,4,5-trimethoxybenzoa te and its acid addition salts.
Dependencies are inferred from the claim text.