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US 3,941,825 AGranted
Substituted aminobenzylideneamino guanidine compounds
AssigneeAmerican Cyanamid Company
InventorAndrew Stephen Tomcufcik
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Abstract
The preparation of 1-amino-3-(4- and 3,4-substituted benzylideneamino)guanidine and the acid addition salts thereof, and their use as intermediates in the preparation of 1,3-bis(4- and 3,4-substituted benzylideneamino)guanidines and their acid addition salts. The final compounds prepared from the present intermediates have antiprotozoal activity particularly against coccidiosis and malaria.
Claims6
A substituted guanidine of the formula:
- ##EQU10## wherein R.sub.1 is selected from the group consisting of halogen, trifluoromethyl, trifluoromethoxy and cyano, R.sub.2 is hydrogen or chlorine and X is the anion of pharmacologically acceptable acid.
Dependencies are inferred from the claim text.