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US 3,941,821 AGranted
2-Thiosulfo biphenylylacetic acids
AssigneeWilliam H. Rorer, Inc.
InventorsJulius Diamond, Norman Julian Santora
Life of this patent
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Abstract
Novel .alpha.-mercapto-p-biphenylylacetic acids and their derivatives have been prepared. Compounds of this invention possess useful anti-inflammatory, analgesic and antipyretic properties.
Claims11
A compound of the formula:
- ##SPC33##
- where:
- R.sub..alpha. is hydrogen or loweralkyl;
- R' and R are hydrogen or not more than one of R or R' at the same time is
- halo,
- nitro,
- amino,
- acylamino,
- mono- and diloweralkylamino,
- mercapto,
- acylthio,
- loweralkylthio,
- loweralkylsulfinyl,
- loweralkylsulfonyl,
- hydroxy,
- loweralkoxy,
- acyloxy,
- haloloweralkyl,
- cyano,
- acetyl or
- loweralkyl;
- X is
- thiosulfo;
- and
- Z is --OH or
- --OM where M is an alkali, alkaline earth or aluminum metal or an ammonium salt.
23 more elements
A compound of the formula:
- ##SPC37##
- where:
- R.sub..alpha. is
- hydrogen,
- methyl or
- ethyl,
- R' is
- chloro,
- bromo,
- nitro,
- methylsulfonyl,
- trifluoromethyl or
- cyano;
- X' is
- sulfo;
- and the alkali, alkaline earth, aluminum metal or ammonium salts thereof.
13 more elements
A compound which is .alpha.-thiosulfo-2'-chloro-4-biphenylylacetic acid and its alkali, alkaline earth or aluminum metal or ammonium salts.
Dependencies are inferred from the claim text.