Process for obtaining D(-)-and L(+)-.alpha.-azidophenylacetic acid
AssigneeDynamit Nobel Aktiengesellschaft
InventorsGunter Bison, Hans Schubel, Gerhard Schmeling
Life of this patent
Estimating the term…
Abstract
L(+)- or D(-)-.alpha.-azidophenylacetic acid is produced by a process which involves the steps of reacting a water-soluble salt of DL-.alpha.-azidophenylacetic acid with a water-soluble salt of an optically active .alpha.-phenylethylamine in an aqueous medium, effecting crystallization of the resulting reaction product, that is, the diastereomeric salt, and splitting of the thus-obtained salt.
Claims15
A process for obtaining L(+)- or D(-)-.alpha.-azidophenylacetic acid which comprises reacting a water-soluble salt of DL-.alpha.-azidophenylacetic acid with a water-soluble salt of optically active .alpha.-phenylethylamine in an aqueous medium containing solvent consisting essentially of water to produce a reaction product therein, crystallizing a diastereomeric salt of said acid and said amine from said reaction product and splitting the thus-obtained salt, said salt of optically active .alpha.-phenylethylamine being utilized in an amount of from 0.1 to 0.5 mole per mole of the salt of DL-.alpha.-azidophenylacetic acid.
Dependencies are inferred from the claim text.