3-Halomethylcarbonyl-9-benzoyl-1,2,3,4-tetrahydrocarbazoles

Abstract

Novel 3-Z-9-benzoyl-1,2,3,4-tetrahydrocarbazoles, wherein Z is CONR.sub.5 R.sub.6, CONHOH, CN, or COCH.sub.2 X, where X is chloro or bromo, having antimicrobial and/or anti-inflammatory activity are disclosed. Compounds wherein Z is CONR.sub.5 R.sub.6 and CONHOH are prepared from the corresponding 3-carboxylic acids by conversion to the corresponding acid chlorides and subsequent reaction with the appropriate amines and hydroxylamine respectively; compounds where Z is CN are prepared by the dehydration of the corresponding compounds where Z is CONH.sub.2 ; and the compounds where Z is COCH.sub.2 X are prepared by reacting hydrogen chloride or bromide with the corresponding compounds where Z is COCHN.sub.2 which in turn is prepared from the corresponding 3-carboxylic acid chloride by reaction with diazomethane.

Dependencies are inferred from the claim text.