6-Substituted-11b-phenyl-3, 11bH-oxazirino[2,3-d]-s-triazol[4,3-a][1,4]benzodiazepines
AssigneeCiba-Geigy Corporation
InventorsHans Allgeier, Andre Gagneux
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Abstract
Compounds of the class of 6-substituted 11b-phenyl-3,11b-oxazirino[2,3-d]-s-triazolo[4,3-a][1,4]benzodiazepines have valuable pharmacological properties and are active ingredients for therapeutic compositions. In particular, these new compounds have an anticonvulsive action and inhibit somatic reflexes. Specific embodiments are 10-chloro-11b-phenyl-3,11bH-oxazirino[2,3-d]-s-triazolo[4,3-a][1,4] benzodiazepine-6-methanol, 10-chloro-11b-phenyl-3,11bH-oxazirino[2,3-d]-s-triazolo[4,3-a][1,4]benzodi azepine-6-carboxaldehyde-diethylacetal and 10-chloro-11b-(o-chlorophenyl)-3,11bH-oxazirino[2,3-d]-s-triazolo[4,3-a][1 ,4]benzodiazepine-6-carboxaldehyde-diethylacetal.
Claims6
A diazepine derivative having the formula I ##SPC4##
- wherein
- R.sub.1 represents hydrogen or an alkyl group having 1 to 3 carbon atoms,
- A represents an alkylene group having 1 to 3 carbon atoms,
- R.sub.2 represents a hydroxyl group, benzyloxy, o-, m- or p-chlorobenzyloxy o-, m- or p-methylbenzyloxy, o-, m- or p-methoxybenzyloxy, or diphenylmethoxy group, or
- R.sub.2 --a together represent a dialkoxymethyl group of which the alkoxy radicals contain 1 to 4 carbon atoms, and
- each of the rings B and C, independently of the other, is unsubstituted or mono-substituted by halogen up to atomic number 35, trifluoromethyl, alkyl or alkoxy groups having 1 to 6 carbon atoms.
Dependencies are inferred from the claim text.