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US 3,941,797 AGranted
4-(Hydroxy-substituted-amino)-furo[3,2-c]pyridines
AssigneeSandoz Ltd.
InventorWilliam R. Simpson
Life of this patent
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Abstract
Disclosed are compounds of the class of furo[3,2-c]pyridines substituted at the 4-position by an amino function bearing a hydroxy-alkyl nitrate moiety, e.g., 4-[ 4-(2-hydroxyethyl)-1-piperazino]-furo[3,2-c]pyridine nitrate. The compounds have pharmacological activity in animals and are useful, for example, as anti-anginal agents. Also disclosed are the corresponding hydroxy intermediates which are useful in preparation of the nitrates and also as anti-anginal agents or as agents in the treatment of shock.
Claims12
A compound of the formula:
- ##SPC6##
- wherein
- R is from the group of:
- a. --CH.sub.2 (--CH.sub.2).sub.n --ONO.sub.2 ##EQU6## d. --CH.sub.2 (--CH.sub.2).sub.z --N[--CH.sub.2 (--CH.sub.2).sub.y --ONO.sub.2 ].sub.2
- R.sub.1 is from the group of:
- e. --CH.sub.2 (--CH.sub.2).sub.n --ONO.sub.2 when R is a) as above defined,
- f. hydrogen or alkyl of 1 to 4 carbon atoms,
- R' is --(CH.sub.2 --).sub.x CH.sub.3 or --(CH.sub.2 --).sub.y ONO.sub.2,
- R.degree. is hydrogen, --(CH.sub.2 --).sub.m CH.sub.3 or --(CH.sub.2 --).sub.y ONO.sub.2, provided that one R.degree. is other than hydrogen, that the sum of n and m does not exceed 7 and the sum of n and y does not exceed 8,
- n is 1 to 7,
- m is 0 to 4,
- x is 0 to 1,
- y is 1 to 4, and
- z is 1 to 4, or
- a pharmaceutically acceptable acid addition salt thereof.
12 more elements
Dependencies are inferred from the claim text.