N-Aryl-N'-(phenyl-or phenoxy-alkyl)-piperazines and salts thereof

Abstract

Compounds of the formula ##EQU1## wherein R is phenyl; phenyl having one or more substituents attached thereto, said substituents being selected from the group consisting of alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio of 1 to 4 carbon atoms, halogen and trifluoromethyl; a bicyclic aromatic or cycloaliphatic-aromatic ring, especially naphthyl, tetrahydronaphthyl or indanyl; or a mono- or bicyclic heterocyclic ring, especially pyridyl, pyrimidyl, isoquinolyl or thiazolyl; R.sub.1 is ##EQU2## where B is ##EQU3## n is 2, 3 or 4, R.sub.3 is hydrogen, alkyl of 1 to 4 carbon atoms or alkanoyl of 1 to 4 carbon atoms, R.sub.4 and R.sub.5, which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 4 carbon atoms, p is 0 or 1, and Q is oxygen or two hydrogens, R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or halogen, A is a single carbon-to-carbon bond or --OCH.sub.2 --, R.sub.6 is hydrogen, hydroxyl, alkoxy of 1 to 4 carbon atoms or alkanoyloxy of 1 to 4 carbon atoms, and m is 0, 1, 2, 3, 4 or 5, but other than 0 when R.sub.6 is hydroxyl, And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as CNS-depressants, adrenolytics, antiphologistics, analgesics, antihistamines and anticholesterols.

Dependencies are inferred from the claim text.