Benzimidazole derivatives
AssigneeRichter Gedeon Vegyeszeti Gyar Rt.
InventorsOlga Hankovszky, Kalman Hideg, Sandor Pacsa
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AssigneeRichter Gedeon Vegyeszeti Gyar Rt.
InventorsOlga Hankovszky, Kalman Hideg, Sandor Pacsa
Estimating the term…
New benzimidazole derivatives of the general formula (I) ##SPC1## and acid addition salts thereof, wherein R.sub.1 and R.sub.2 each represent hydrogen or methyl, R.sub.5 and R.sub.6 form together a valence bond and at the same time R.sub.3 and R.sub.4 form together a group of the general formula (II), ##EQU1## wherein n is equal to zero or one, or R.sub.4, R.sub.5 and R.sub.6 form together a group of the formula (III) ##EQU2## and at the same time R.sub.3 stands for benzyl group, were prepared by reacting a compound of the general formula (IV), ##SPC2## wherein R.sub.7 stands for hydrogen or benzyl group and R.sub.1, R.sub.2 and n each have the same meanings as defined above, or an acid addition salt thereof with epichlorohydrine optionally in the presence of a base. The new compounds of the general formula (I) and their acid addition salts inhibit the reproduction of viruses and can be used in therapy as antiviral agents.
a compound of the formula (I) ##SPC5##
1,2,3,4-Tetrahydro-3-hydroxy-pyrimido[1,2-a]benzimidazole or the hydrochloride addition salt thereof.
3,4-Dihydro-3-hydroxy-7,8-dimethyl-10-benzyl-2H -pyrimido[1,2-a]benzimidazoline or the hydrochloride addition salt thereof.
Dependencies are inferred from the claim text.