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US 3,941,787 AGranted
1,4-Disubstituted-5,8-methano-tetrahydro-quinazolinones
AssigneeSandoz Ltd.
InventorWilliam G. Salmond
Life of this patent
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Abstract
Anti-inflammatory agents of the formula I: ##SPC1## wherein R is lower alkyl, cycloalkyl or cycloalkylalkyl, R' is a radical of the formula ##SPC2## in which Y and Y' are hydrogen, lower alkyl, lower alkoxy, halo or trifluoromethyl, or a radical of the formula ##SPC3## in which Y" is hydrogen, halo or alkyl, Are prepared by cyclizing a compound of formula II ##SPC4## in which R and R' are as defined above, with phosgene.
Claims10
A compound of the formula ##SPC15##
- wherein:
- R is lower alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms or cycloalkylalkyl of 4 to 10 carbon atoms in which the cycloalkyl is of 3 to 8 carbon atoms and the alkyl of 1 to 3 carbon atoms,
- R' is a radical of the formula ##SPC16##
- in which Y and Y' are the same or different and represent hydrogen, halo of atomic weight of 18 to 36, alkyl having from 1 to 2 carbon atoms, alkoxy having from 1 to 2 carbon atoms, or one of Y and Y' is trifluoromethyl while the other is hydrogen, or a radical of the formula ##SPC17##
- in which Y" is hydrogen, halo of atomic weight of from 18 to 36 or alkyl of 1 to 3 carbon atoms.
2 more elements
Dependencies are inferred from the claim text.