Process for the production of 4-hydroxy-6-hydroxymethylpyrimidine
AssigneeLonza Ltd.
InventorErich Greth
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Abstract
Process for the production of 2-R.sup.1 substituted-4- hydroxy-5-R.sup.2 substituted -6-hydroxy methyl-pyrimidines having the following general formula: ##EQU1## wherein R.sup.1 can be an alkyl group, a phenyl group or --H, and wherein R.sup.2 can be an alkyl group, a phenyl group or --H. The process includes reacting a 2-R.sup.1 substituted -4-hydroxy-5-R.sup.2 substituted -6-chloromethyl-pyrimidine having the following general formula: ##EQU2## wherein R.sup.1 and R.sup.2 are defined as above, with water under reflux at a pH value of 4 to 8.
Claims24
A process for the production of 2-R.sup.1 substituted-4-hydroxy -5-R.sup.2 substituted-6-hydroxymethyl-pyrimidines having the following formula:
- wherein R.sup.1 can be an alkyl group having 1 to 10 carbons, phenyl group or --H, and wherein R.sup.2 can be an alkyl having 1 to 10 carbons, a phenyl group or --H, which comprises reacting a 2-R.sup.1 substituted-4-hydroxy-5-R.sup.2 substituted-6-chloromethyl-pyrimidine having the following formula:
- ##EQU11## wherein R.sup.1 and R.sup.2 are defined above, with water under reflux at a pH value of 4 to 8, said pH not being outside the stated range during said reaction.
Dependencies are inferred from the claim text.