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US 3,940,441 AGranted
N,N'-bisphenoxybenzyl-bridged-diamides
AssigneeSterling Drug Inc.
InventorAlexander R. Surrey
Life of this patent
Estimating the term…
Abstract
Alkylenediamine derivatives substituted on each nitrogen atom by 4-(4'-nitrophenoxy)benzyl or 4-(4'-aminophenoxy)benzyl, optionally substituted additionally on each nitrogen by lower-alkyl, phenylcarbamyl or dihaloacetyl and optionally interrupted in alkylene by cycloalkylene, phenylene, alkylated-phenylene, pyridylene, furylene and thiazolylene. The compounds, which have antibacterial activity, are prepared stepwise by reacting an alkylenediamine with two molar equivalents of 4-(4'-nitrophenoxy)benzaldehyde and reducing the resulting bis(benzal)alkanediamines.
Claims5
A compound of the formula ##SPC4##
- wherein Z is nitro or amino;
- R is phenylcarbamyl or dihaloacetyl;
- and Y is alkylene having from two to ten carbon atoms and having its connecting linkages on different carbon atoms or said alkylene interrupted by O, S, NH, N(lower-alkyl), cycloalkylene having from three to six ring carbon atoms, phenylene or phenylene having from one to four lower-alkyl substituents.
Dependencies are inferred from the claim text.