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US 3,940,438 AGranted
Crystalline racemic 9.alpha.,11.alpha.,15(S)-trihydroxy-5-cis,13-trans-prostadienoic acid
AssigneeAlza Corporation
InventorNed M. Weinshenker
Life of this patent
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Abstract
The invention concerns a novel crystalline racemate, 9.alpha.,11.alpha.,15(S)-trihydroxy-5-cis,13-trans-prostadienoic acid. The racemate can be administered in pharmaceutical dosage forms or from a drug delivery device at a programmed rate for producing smooth muscle stimulation, termination of pregnancy, induction of labor or induction of menses.
Claims1
Crystalline, racemate 9.alpha.,11.alpha.,15(S)-trihydroxy-5-cis,-13-trans-prostadienoic acid wherein the crystals are characterized by the following X-ray diffraction data:
- Interplanar Spacings, A.degree. ______________________________________ 27.60 4.65 18.19 4.09 13.00 3.54 10.33 3.30 8.38 2.98 7.31 2.79 6.06 2.63 5.40 2.53 4.92 2.04 4.67 ______________________________________
- and wherein the crystals system is monoclinic, the crystal habit is tubular, the optic sign is negative, and the melting point is 63.5.degree. C to 64.degree. C.
Dependencies are inferred from the claim text.