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US 3,940,413 AGranted
1-Ethyl-imidazoles
AssigneeBayer Aktiengesellschaft
InventorsWolfgang Kramer, Karl Heinz Buchel, Werner Meiser, Manfred Plempel
Life of this patent
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Abstract
1-Ethyl-imidazoles of the formula ##SPC1## Or a pharmaceutically acceptable nontoxic salt thereof, are produced by A. reacting a compound of the formula ##SPC2## With imidazole; or B. when R.sup.1 is hydrogen, reacting a compound of the formula ##SPC3## With imidazole in the presence of an acid binding agent. In the case of the salts the free base produced is reacted with an appropriate acid. The 1-ethyl-imidazoles are useful for their antimycotic activity.
Claims29
A compound of the formula ##SPC13##
- wherein
- R.sup.1 and R.sup.3 are the same or different and are hydrogen, straight or branched-chain lower alkyl, straight or branched-chain lower alkenyl, cycloalkyl of 3 to 7 carbon atoms, cycloalkenyl of 5 to 7 carbon atoms, aryl of 6 to 10 carbon atoms unsubstituted or substituted by 1 to 3 of the same or different substituents selected from the group consisting of halogen, halogenoalkyl of 1 or 2 carbon atoms in the alkyl moiety and 2 to 5 halogen atoms, straight or branched-chain alkyl of 1 to 4 carbon atoms, straight or branched-chain alkoxy of 1 to 4 carbon atoms, thioalkyl of 1 to 4 carbon atoms, alkylsulphonyl of 1 to 4 carbon atoms, nitro, cyano, phenyl and hydroxymethyl-substituted phenyl, or aralkyl of 6 to 10 carbon atoms in the aryl moiety and 1 to 4 carbon atoms in the alkyl moiety unsubstituted or substituted by 1 to 3 of the same or different substituents selected from the group consisting of halogen, halogenoalkyl of 1 or 2 carbon atoms in the alkyl moiety and 2 to 5 halogeno moieties, straight or branched-chain alkyl of 1 to 4 carbon atoms, straight or branched-chain alkoxy of 1 to 4 carbon atoms, thioalkyl of 1 to 4 carbon atoms, alkylsulphonyl of 1 to 4 carbon atoms, nitro, cyano, phenyl or hydroxymethyl-substituted phenyl;
- R.sup.2 is straight or branched-chain lower alkyl, straight or branched-chain lower alkynyl, cycloalkyl of 3to 7 carbon atoms, cycloalkenyl of 5 to 7 carbon atoms, aryl of 6 to 10 carbon atoms unsubstituted or substituted by 1 to 3 of the same or different substituents selected from the group consisting of halogen, halogenoalkyl of 1 or 2 carbon atoms in the alkyl moiety and 2 to 5 halogeno moieties, straight or branched-chain alkyl of 1 to 4 carbon atoms, straight or branched-chain alkoxy of 1 to 4 carbon atoms, thioalkyl of 1 to 4 carbon atoms, alkylsulphonyl of 1 to 4 carbon atoms, nitro, cyano, phenyl and hydroxymethyl-substituted phenyl, or aralkyl of 6 to 10 carbon atoms in the aryl moiety and 1 to 4 carbon atoms in the alkyl moiety unsubstituted or substituted by 1 to 3 of the same or different substituents selected from the group consisting of halogen, halogenoalkyl of 1 or 2 carbon atoms in the alkyl moiety and 2 or 5 halogen moieties, straight or branched-chain alkyl of 1 to 4 carbon atoms, straight or branched-chain alkoxy of 1 to 4 carbon atoms, thioalkyl of 1 to 4 carbon atoms, alkylsulphonyl of 1 to 4 carbon atoms, nitro, cyano, phenyl and hydroxymethyl-substituted phenyl;
- X is C=O;
- and
- Y is oxygen or sulphur;
- or a pharmaceutically acceptable nontoxic salt thereof.
4 more elements
Dependencies are inferred from the claim text.