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AssigneeCassella Farbwerke Mainkur Aktiengesellschaft
InventorsThomas Raabe, Josef Scholtholt, Rolf-Eberhard Nitz
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The present invention relates to pharmacologically valuable new derivatives of 1-phenoxy-3-amino-propane-2-ol and process for their production. The new derivatives of 1-phenoxy-3-amino-propane-2-ol are suitable for the treatment and prophylaxis of diseases of the heart. Some possess pronounced .beta.-adrenalytic or anti-arythmic properties. These new derivatives have the structural formula ##SPC1## Wherein X signifies ##SPC2## And the phenyl nucleus I may be mono-, di- or trisubstituted by alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, alkoxy, alkenyloxy, phenyl, halogen or the radical --NR.sub.1 R.sub.2, in which R.sub.1 stands for alkyl or acyl and R.sub.2 for hydrogen or alkyl, together with their aldehyde condensation products and their acid addition salts.
Derivative of 1-phenoxy-3-amino-propane-2-ol of the formula ##SPC59## in which X denotes ##SPC60## ##SPC61##
(-)-1-(3'-.beta.-Pyridyl-3'-hydroxy-1'-methylpr opylamino)-3-(o-ethoxy-phenoxy)-propan-2-ol, laevo-rotatory and its acid addition salts.
1-(3'-.beta.- Pyridyl-3'-hydroxy-1'-methyl-propylamino)-3-(p-acetamino-phenoxy)-propan-2- ol. and its addition salts.
1-(3'-.beta.-Pyridyl-3' -hydroxy-1'-methyl-propylamino)-3-(m-methoxyphenoxy)-propan-2-ol and its acid addition salts.
1-(3'-.beta.-Pyri dyl-3'-hydroxy-1'-methyl-propylamino)-3-(o-chlorophenoxy)-propan-2-ol and its acid addition salts.
1-(3'-.beta.-Pyridyl- 3'-hydroxy-1'-methyl-propylamino)-3-(p-methoxyphenoxy)-propan-2-ol and its acid addition salts.
Dependencies are inferred from the claim text.