Back to results
US 3,940,404 AGranted
2-Substituted phenyl-6-trifluoromethyl-4-pyridyl-carbinolamines
AssigneeThe United States of America as represented by the Secretary of the Army
InventorsArthur B. Ash, Maurice P. La Montagne, Anica Markovac
Life of this patent
Estimating the term…
Abstract
A series of 2-aryl-6-trifluoromethyl-4-pyridylcarbinolamines is herein disclosed which has value in treatment of plasmodial infections. The compounds have substituted phenyl groups at position 2- on the pyridine moiety, with the electronegative substituents present on the phenyl nuclei. The syntheses of such series is described, together with a method for separation of racemates of a representative 4-pyridylcarbinolamine type.
Claims5
Compound of the formula ##SPC5##
- and pharmaceutically acid addition salts thereof wherein
- R is hydrogen, while
- R.sub.1 is hydrogen,lower-alkyl, or cycloalkyl of 3 to 10 carbon atoms
- R.sub.2 is lower-alkyl or cycloalkyl of 3 to 10 carbon atoms,R.sub.2 being the same or different as R.sub.1 ;
- and
- (Ar).sub.2 is phenyl substituted by one trifluoromethyl,
- chloro, bromo, fluoro or methoxy substituent in the phenyl ring.
4 more elements
Dependencies are inferred from the claim text.