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US 3,940,398 AGranted
2-[[4-(Azine or diazine or triazine)-1-piperazinyl]alkyl]-1H-benz[de]isoquinoline-1,3(2H)-diones
AssigneeE. R. Squibb & Sons, Inc.
InventorsPeter C. Wade, Berthold Richard Vogt
Life of this patent
Estimating the term…
Abstract
Compounds of the following formula and their acid addition salts ##SPC1## Wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, amino and trifluoromethyl; A is a straight or branched chain alkylene of 1 to 8 carbons; and R is a 6-membered unsaturated substituted or unsubstituted heterocyclic ring selected from pyridine, diazine and triazine are disclosed. These compounds exhibit antidepressant activity. In addition these compounds are also useful as antiinflammatory agents.
Claims12
A compound of the formula:
- ##SPC16##
- wherein R.sup.1 and R.sup.2 are each independently selected from the group consisting of hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, amino, and trifluoromethyl;
- A is a straight or branched chain alkylene of 1 to 8 carbons;
- and R is a heterocyclic ring selected from the group consisting of pyridinyl, diazine, triazine, and substituted pyridinyl, diazine, or triazine, wherein said heterocyclic ring is attached to the piperazine by way of an available carbon atom and said substituent is a lower alkyl, lower alkoxy, or halogen group attached to one or two available carbon atoms of said heterocyclic ring;
- or the pharmaceutically acceptable acid addition salts thereof.
2 more elements
Dependencies are inferred from the claim text.