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US 3,940,397 AGranted
2-[(Substituted-piperazinyl)alkyl]-1H-benz[de]isoquinoline-1,3(2H)-diones
AssigneeE. R. Squibb & Sons, Inc.
InventorsPeter C. Wade, Berthold Richard Vogt
Life of this patent
Estimating the term…
Abstract
Compounds of the following formula and their acid addition salts ##SPC1## Wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, amino and trifluoromethyl; A is a straight or branched chain alkylene of 1 to 8 carbons; and Z is ##SPC2## Wherein R.sup.3 is selected from phenyl, phenyl-lower alkyl, and substituted phenyl and phenyl-lower alkyl are disclosed. These compounds exhibit antidepressant activity. In addition these compounds are useful as antiinflammatory agents.
Claims22
A compound of the formula ##SPC12##
- wherein R.sup.1 and R.sup.2 are each independently selected from the group consisting of hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, amino, and trifluoromethyl;
- A is a straight or branched chain alkylene of 1 to 8 carbons;
- and Z is ##SPC13##
- wherein R.sup.3 is selected from the group consisting of phenyl, phenyl-lower alkyl and substituted phenyl and phenyl-lower alkyl and said phenyl substituents are one or more selected from the group consisting of halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, amino, and trifluoromethyl;
- or the pharmaceutically acceptable acid addition salts thereof.
2 more elements
Dependencies are inferred from the claim text.