2-pyrimidinylthio)alkanoic acids, esters, amides and hydrazides
OwnerArthur A. Santilli, Anthony C. Scotese +1inventors
InventorsArthur A. Santilli, Anthony C. Scotese, Rudolph M. Tomarelli
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Abstract
(2-Pyrimidinylthio)alkanoic acid, esters, amides and hydrazides as well as various 4- and 6-substituted derivatives thereof as depicted by the structural formula: ##SPC1## In which R and R.sup.2 are independently --H or lower alkyl; R.sup.1 is --H, -halo or lower alkoxy; Z is --OH, OM, lower alkoxy or --(NH).sub.1 --NH.sub.2, wherein p is 0 to 1 and M is an alkali metal, alkaline earth metal or ammonium cation; Y is an aryl, amino or substituted amino radical; and m is an integer from 0 to 2, exhibit anti-lipemic activity in warm-blooded animals.
Claims3
A compound of the formula:
- ##SPC13##
- in which
- R, r.sup.2, r.sup.7, r.sup.8 and R.sup.9 are independently hydrogen or lower alkyl;
- R.sup.5 is lower alkyl, lower alkoxy, aryl of 6 to 10 carbon atoms, haloaryl of 6 to 10 carbon atoms or halo;
- R.sup.6 is hydrogen, lower alkyl, halo or lower alkoxy;
- n is one of the integers 0, 1, 2 or 3;
- provided that when n is 0 and R.sup.5 is lower alkoxy, R.sup.6 is lower alkyl, halo or lower alkoxy;
- and
- Z is --OH, --OM, lower alkoxy or --(NH).sub.p --NH.sub.2, in which p is one of the integers 0 or 1 and M is an alkali metal, alkaline earth metal or ammonium cation.
Dependencies are inferred from the claim text.