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US 3,940,393 AGranted
Synthesis of 2,6-diaminopyrimidines
AssigneeAmerican Home Products Corporation
InventorsGeorge Greenspan, Richard W. Rees, Peter B. Russell
Life of this patent
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Abstract
New, substituted, 2,6-diaminopyrimidines are disclosed. These compounds are useful as anti-malarial agents. The oxygenation of pyrimethamine by fungi is also disclosed.
Claims10
A compound of the formula:
- ##SPC5##
- wherein R is phenyl, 3-chlorophenyl, 4-chlorophenyl, or 3,4-dichlorophenyl, X is C(OCH.sub.3).sub.2, C(OC.sub.2 H.sub.5).sub.2, C=O, C=N--OH, C=N--NH.sub.2, C=N--N(CH.sub.3).sub.2, CHOH, or ##EQU6## R.sup.1 is alkyl of from 1 to 6 carbon atoms;
- and their pharmacologically acceptable acid addition salts.
Dependencies are inferred from the claim text.