Streptozotocin analogs
AssigneeStanford Research Institute
InventorsAllan N. Fujiwara, Edward M. Acton, David W. Henry
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Abstract
New 3-methyl-3-nitrosoureido derivatives of the following amino sugars were prepared as analogs of streptozotocin with the anomeric carbon protected, by nitrosating the methylureas in water with N.sub.2 O.sub.3 : 3-amino-3-deoxy-1,2-O-isopropylidene-.alpha.-D-ribofuranose; methyl 3-amino-3-deoxy-.beta.-D-xylopyranoside; methyl 3-amino-3-deoxy-.alpha.-D-altropyranoside; methyl 3-amino-3-deoxy-.alpha.-D-glucopyranoside; and methyl 3-amino-2,3,6-trideoxy-.alpha.-L-lyxohexopyranoside. Tests against murine leukemia L1210 show that the anticancer activity of streptozotocin not only was retained but was enhanced in most of these derivatives.
Claims6
The 3-methyl-3-nitrosoureido derivatives of the following amino sugars:
- methyl 3-amino-3-deoxy-.beta.-D-xylopyranoside;
- methyl 3-amino-3-deoxy-.alpha.-D-altropyranoside;
- 3-amino-3-deoxy-1,2-O-isopropylidene-.alpha.-D-ribofuranose;
- methyl 3-amino-2,3,6-trideoxy-.alpha.-L-lyxohexopyranoside;
- and methyl 3-amino-3-deoxy-.alpha.-D-glucopyranoside.
Dependencies are inferred from the claim text.