Antidepressive and antianxiety composition comprising 2-pyrazolyl-benzophenones

An antidepressive and antianxiety pharmaceutical composition comprising a antidepressively or anxiolytic effective amount of a compound corresponding to the formulae ##EQU5## wherein Ar is unsubstituted phenylene, or phenyl substituted by one or two, of the same or different substituents selected from the group consisting of lower alkyl, lower alkoxy, halo or trifluoromethyl, Ph is 1,2-phenylene substituted by one or two halogen atoms, R.sub.o is hydrogen, lower alkyl, (hydroxy, lower alkoxy or Am)C.sub.m H.sub.2m or Ar-C.sub.n H.sub.2n, wherein Am is amino, mono- or di-lower alkylamino, lower alkyleneimino or mono-aza-, oxa- or thia-alkyleneimino, wherein the additional nitrogen, oxygen or sulfur atom is separated from the iminonitrogen by at least 2 carbon atoms, m is an integer from 1 to 7, n such from 0 to 7, each of R.sub.1, R.sub.2 and R.sub.3 is hydrogen or lower alkyl, and X is oxo, thio or hydrogen and hydroxy or lower alkoxy, simple or mixed, open or cyclic lower alkyl or alkylene ketals thereof;

• or a lower alkanoyl, alkoxycarbonyl, AmCO or AmCS derivative of the compounds containing at least one hydrogen attached to oxygen or nitrogen;
• or a therapeutically useful acid addition salt thereof, together with an enterally or parenterally applicable pharmaceutical excipient.