Method for contraception by the administration of sequential contraceptive preparations
AssigneeSchering Corporation
InventorUrsula Lachnit-Fixson
Life of this patent
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Abstract
Oral contraceptive consisting essentially in admixture with a pharmaceutically acceptable carrier, of 21-23 separate dosage units adapted for oral ingestion, containing an amount of an estrogen corresponding in activity to 0.030-0.050 mg. 17.alpha.-ethinylestradiol, with the first 10-12 dosage units being in combination with a gestagen corresponding in activity to about 0.050-0.125 mg. of d-norgestrel and the remainder in combination with a gestagen corresponding in activity to 2-3 times the amount of gestagen in the first 10-12 units.
Claims6
A method of oral contraception which comprises administering orally to a female of child-bearing age an estrogen at a daily dosage of 0.050 mg. of 17.alpha.-ethinylestradiol for 21 days of her menstrual cycle, either (a) in combination the first 11 days with 0.050 mg. per day of d-norgestrel followed for the next 10 days by 0.125 mg. per day of d-norgestrel, or (b) in combination the first 11 days with 1 mg. of 17.alpha.-ethinyl-19-nortestosterone acetate followed for the next 10 days by 2 mg. per day of 17.alpha.-ethinyl-19-nortestosterone acetate.
A two-stage combination oral contraceptive composition consisting essentially of 21 separate dosage units adapted for successive daily oral ingestion and each containing in admixture with a pharmaceutically acceptable carrier, 0.050 mg. of 17.alpha.-ethinylestradiol and either (a) 0.050 mg. of d-norgestrel in the first 11 dosage units and 0.125 mg. of d-norgestrel in the next 10 dosage units, or (b) 1 mg. of 17.alpha.-ethinyl-19-nortestosterone acetate in the first 11 dosage units and 2 mg. of 17.alpha.-ethinyl-19-nortestosterone acetate in the next 10 dosage units, any other dosage units being free of estrogenic and gestagenic agents.
Dependencies are inferred from the claim text.