Method for preparing aldehydes
OwnerAlbert Eschenmoserinventor
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Abstract
A process for the manufacture of aldehydes of the general formula ##EQU1## in which the symbols R.sub.1, R.sub.2 and R.sub.3 stand for hydrogen or organic radicals and in which at least two of these radicals are linked together by fragmenting a corresponding aziridine compound of the general formula ##EQU2## in which R.sub.1, R.sub.2 and R.sub.3 are as above and R.sub.4 to R.sub.7 each represents hydrogen, an alkoxycarbonyl, cyano, nitro or sulphonyl group or an alkyl, alkenyl, cycloalkenyl or alkyl residue and two or more of these residues may be linked together with simultaneous evolution of nitrogen.
Claims13
Process for the manufacture of an aldehyde of the formula ##EQU11## in which either R.sub.1 and R.sub.3 together represent alkylene with 2 or 3 chain carbon atoms, or R.sub.2 and R.sub.3 together represent alkylene with 3 or 4 chain carbon atoms and the remaining R.sub.2 or R.sub.1 is hydrogen or lower alkyl, which comprises condensing a compound of the formula ##EQU12## wherein R.sub.1, R.sub.2 and R.sub.3 have the above meanings, with the aminoaziridine of the formula ##EQU13## in which R.sub.4, R.sub.5, R.sub.6 and R.sub.7 each represents a member selected from hydrogen, lower alkyl, lower alkenyl, lower cycloalkyl, phenyl, tetrahydronaphthyl or phenyl substituted by at least one halogen, lower alkyl or phenyl, or R.sub.5 and R.sub.6 together are alkylene with 3 to 5 carbon atoms and R.sub.4 and R.sub.7 are hydrogen, at about room temperature and heating the condensation product to about 170.degree. until the evolution of molecular nitrogen ceases.
Dependencies are inferred from the claim text.